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Given its role in catalyzing the conversion of pyruvate to lactate in glycolytic cancer cells and the observation that LDHA deficiency results in only relatively mild symptoms, such as exertional myopathy, LDHA represents a pivotal and safe therapeutic target (150,167)
For most people, symptoms resolve completely at lower doses
Recently, pharmacologic agonists of glucose-dependent insulinotropic polypeptide (GIP), an incretin synthesized in the K-cells of the duodenum and jejunum, have also become available
Drug Metab Dispos 34:16001605 [DOI] [PubMed] [Google Scholar] Meijering E, Jacob M, Sarria JC, Steiner P, Hirling H, Unser M
Combination of the protein structure for molecular docking was performed with UCSF ChimeraX, developed by the Resource for Biocomputing, Visualization, and Informatics at the University of California, San Francisco, with support from National Institutes of Health R01-GM129325 and the Office of Cyber Infrastructure and Computational Biology, National Institute of Allergy and Infectious Diseases
