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Glucagon-like peptide-1 (GLP-1) and its split products GLP-1(9-37) and GLP-1(28-37) stabilize atherosclerotic lesions in apoe(-)/(-) mice

Phase Phase 4 Mid maintenance Weeks Weeks 1316 Dose 10 mg once weekly Notes Second maintenance dose

The balanced ratio of GLP-1 to glucagon receptor activity ensures that the hyperglycemic potential of glucagon signaling is offset by the insulinotropic and appetite-suppressive effects of GLP-1 signaling, resulting in net improvements in both glycemic parameters and body weight

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Shop Biochem Sports Nutrition Supplements Sources mentioned in this article: Protein- and Calcium-Mediated GLP-1 Secretion: A Narrative Review

JAMA 274:1049-1057 Burk, R.F., B.K