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doi: 10.1007/s00441-015-2113-z

Rybelsus is FDA approved, but not yet approved for weight loss

The American Diabetes Association recommends metformin for the treatment of prediabetes, but its still considered an off-label use

Although not universally observed, studies suggest that individuals taking semaglutide and tirzepatide may experience a significant loss of lean muscle mass, along with fat mass (15-60% of weight loss)