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If semaglutide made up 80% of GLP-1 volume (before Zepbound), that implies compounded share closer to 32% (source) Now, look at Hims: They launched compounded semaglutide in Q2 2024 and reported $225M in GLP-1 revenue through year-end (source)

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Activation of the VTA LepR neurons mainly decreases motivation for feeding and food reward, whereas activation of the SN LepR neurons mainly reduces locomotor activity [81]

The goal of microdosing is not to stay at low doses forever but to establish a foundation of tolerance that makes higher effective doses more comfortable to reach