This finding supports the idea that the initial striatal hyperdopaminergia in Trkb Penk -KO causes long-lasting cellular and molecular changes that induce spontaneous hyperlocomotion
FEEDBACK LOOPS OF GH SECRETION Multiple negative feedback loops exist to autoregulate the GH axis (Figure 7)
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The 16.8% weight loss in this population is substantially below TRIUMPH-1's 28.3% a pattern consistent across the GLP-1 drug class, where type 2 diabetes reduces the magnitude of weight loss compared to non-diabetic obesity populations
[PubMed] Jett, Lucie & Leger, Roger & Thibaudeau, Karen & Benquet, Corinne & Robitaille, Martin & Pellerin, Isabelle & Paradis, Vronique & Wyk, Pieter & Pham, Khan & Bridon, Dominique