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J.AdevaJ.et al

Cystinosin-LKG, the alternatively spliced isoform of cystinosin, has a broader localization that could be leveraged to reduce cystine accumulation, restore lysosomal function, and lower apoptosis rates in cystinotic proximal tubule cells [155]

But many of the roles of MSM and vitamin C overlap, such an antioxidant and cartilage protection, making them an ideal duo in supplemental form

Consequently, inhibition of TXN, TrxR and NADPH can lead to inhibited glutathione uptake, reduced GPX4 levels, increased levels of peroxides and oxidised proteins, and ultimately to iron-mediated cell death