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Propert KJ, Payne C, Kusek JW et al: Pitfalls in the design of clinical trials for interstitial cystitis

But related problems have been documented: Generalized lichenoid reactions: widespread skin inflammation spreading well beyond the tattoo site, sometimes requiring systemic steroids

Its less expensive than newer medications

Overpriced creams with side effects, collagen powders with a nocebo effect, chanting mantras that didnt move the needle and dont get me started on risky surgeries and procedures that wont do much else except cover up underlying symptoms

Vitamin D and microbiota: two sides of the same coin in the immunomodulatory aspects

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