Compared to the free drug, in vitro and in vivo assays showed that gold nanoparticle-conjugated quercetin inhibited angiogenesis and invasion of breast cancer by targeting the EGFR/VEGFR-2 signaling pathway ( in vitro and in vivo anti-angiogenic activity in a breast cancer model that was mediated by suppressing VEGF in cancer cells (Shashni et al., 2021)
A phase II study of nab-paclitaxel in refractory CIMP-high metastatic colorectal cancer
Others contain multiple doses or need to be refilled
However, increasing structural and compositional complexity also introduces challenges related to batch-to-batch reproducibility, long-term biosafety, and regulatory assessment
It has been widely studied for its potential applications in cellular regeneration and tissue repair
For patients requiring long-term treatment, hydrogel carriers can provide continuous drug release and reduce the frequency of administration