Although depletion of CD8 PD-1+ T cells leads to a decrease in their cytotoxic capacity and impaired control of chronic infections or tumors, this phenotype is thought to be adapted to minimize tissue damage while maintaining a critical level of pathogen control (223, 301, 303)
In comparison, the placebo group experienced a decrease of 2.6% equivalent to 2.8 kg
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Similarly, another study reported lower serum GSH levels in women with postmenopausal osteoporosis [23]
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In the meantime, it is recommending that prescribers do not start new patients on the drugs, unless there are no suitable alternatives and theres a clinical reason to do so
