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Finally, Liskiewicz et al (118) recently reported that long-acting GIP agonists and GIPGLP-1 coagonists decrease body weight and food intake via inhibitory GABAergic neurons

In vitro data show that linagliptin has the highest potency for inhibiting DPP-4 among the available DPP-4 inhibitors, with an inhibitory concentration (IC 50 ) of approximately 1 nM (compared with 24 nM for alogliptin, 19 nM for sitagliptin, 50 nM for saxagliptin, and 62 nM for vildagliptin)

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