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Romanini et al., 2019)

Each participant received either a once-weekly Semaglutide dose of 2.4 mg or a placebo (a fake treatment) The trial lasted 68 weeks (about 1 and 1/3 years) At the end of the trial, the participants who received weekly Semaglutide treatments achieved an average of a 14.9% reduction in body weight

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6) using PROPKA, C23 was determined to be the most acidic cysteine ( p K a = 5.4) followed by C8 ( p K a = 7.4), both of which are more acidic than the thiol group in GSH ( p K a = 8.7)