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Efficacy and safety of canagliflozin compared with placebo and sitagliptin in patients with type 2 diabetes on background metformin monotherapy: a randomised trial

10.1038/nature26138 20 GhoshM.GuptaP

GLP-1 medications (glucagon-like peptide-1 receptor agonists) are used mainly for weight management and type 2 diabetes

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On the other hand, preclinical studies report that the activation of MC3R and MC4R by melanotan peptides can result in significant appetite suppression, anorexia, and weight loss [22]