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Several previous experiments using knock-out mice have suggested that TLR2, TLR3, TLR4, TLR9, and RAGE could contribute to APAP-induced liver injury although some controversy remains pertaining to possible dual or opposite effects according to which cell types are studied 29,30,31

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5.1 Genetic mechanisms of riboflavin transport and utilization defects Dietary riboflavin bioavailability depends on coordinated processes including intestinal absorption, cellular uptake, intracellular activation, and mitochondrial transport

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