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In the oxidized state with two nearby cysteines forming a disulfide bond and the third cysteine unmodified, HMGB1 acts as a proinflammatory cytokine (Yang et al., 2021) which can interact with TLR4 (Pauletti et al., 2019)

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Indeed, when we reverted cysteine-deprived Cse / mice to a cysteine-sufficient but B5-deficient diet, they failed to gain as much weight as mice on the control B5 and cysteine-sufficient diet (Fig

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