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[16] Upon oral administration, prednisone undergoes hepatic conversion to prednisolone via 11-beta-hydroxysteroid dehydrogenase type 1, which represents the primary active metabolite responsible for glucocorticoid activity

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Grne E, Crispin A, Fleckenstein J et al (2012) Test order of quantitative sensory testing facilitates mechanical hyperalgesia in healthy volunteers

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