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Paracetamol is generally regarded as a first-line analgesic and is preferred over NSAIDs in certain patient groups

Low SOD + Low GSH/GSSG + High MDA Severe oxidative damage, impaired defenses

doi:10.1007/s40265-018-0963-x

It can be given monthly or every three months

Others remain cautious, preferring to work within the studied protocol and use established side effect management strategies before considering experimental modifications

The following situations require a clinician conversation or same-day care: Contact within 48 hours if: vomiting prevents you from keeping down water for more than eight hours, diarrhea produces signs of dehydration, constipation has not responded to an osmotic laxative after five days, or symptoms worsen at a stable dose after week 12