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Bizzarri M, Lagan AS, Aragona D, Unfer V (2020) Inositol and pulmonary function

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[1] [12] The drug belongs to the biguanide class and has multiple mechanisms of action, including effects associated with AMP-activated protein kinase (AMPK) activation, mitochondrial complex I inhibition, and gut-mediated actions

Importantly, gradual titration over 20 weeks greatly reduces the incidence and severity of GI side effects

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