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Description

Targeting these upstream processes may attenuate ferroptotic epithelial damage and downstream fibroblast activation

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10.1016/j.biochi.2006.10.014 Biochimie 19 ChenL.YangH

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The combined modifications produce a protein that retains full agonist activity at the type 1 IGF receptor (IGF-1R) while binding the IGF binding proteins (IGFBP-1 through IGFBP-6) with substantially reduced affinity

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