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Burns, T., Breathnach, S., Cox, N

We allowed animals to recover for at least 2 weeks to ensure expression of the viral constructs

Key structural characteristics include: The linear structure and conserved melanocortin pharmacophore provide selective MC1R receptor activation while the terminal modifications enhance peptide stability and bioavailability in nasal delivery applications

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Western blot analysis was utilized to measure the expression of GLP-1R, PKA/CREB pathway components and inflammation-related proteins, such as tumor necrosis factor-alpha (TNF-), interleukin-1 beta (IL-1), and IL-6