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Likewise, the origin of the glutathione that accumulates in this compartment remains unclear, as does whether external factors, such as glutathione-rich diets or direct intake of this compound as an antioxidant supplement, might influence its levels in the tumour microenvironment

In rat neural cell lines, EGCG significantly increased the expression of NRF2 and HO-1, inhibited nuclear transcription factor kappa B (NF- B), directly reduced the overproduction of ROS and protected cultured neurons from oxidative stress-induced cell death 167

JAK inhibition increases bone mass in steady-state conditions and ameliorates pathological bone loss by stimulating osteoblast function

10.1038/jcbfm.2008.65 213