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TMAU is a genetic condition in which trimethylamine (TMA), a compound that smells like rotting fish, accumulates in your body
Diagnostic Criteria (Adapted from consensus guidelines): Chronic multisystem symptoms consistent with mast cell activation Evidence of elevated mast cell mediators (during flare or baseline), such as: Serum tryptase Plasma histamine Chromogranin A Urinary N-methylhistamine Urinary prostaglandin D2 or F2 Improvement with medications that block mast cell activity (e.g., antihistamines, cromolyn sodium) Testing is most accurate when done during or soon after a flare , and samples often need to be chilled and analyzed at specialized labs
Since IL-6 can cross the BBB, it may also contribute to producing PGE2 22,60
and (iv) interactions with androgen signaling and metabolic state
Further comprehensive studies are required to validate these findings, ensuring that alterations in microbial composition can be reliably utilised as a diagnostic biomarker for brain tumours