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In cells, it increases expression of canonical ERR target genes and enhances mitochondrial respiration

Its popularity stems from the many benefits it offers

Its use in humans outside an FDA-authorized clinical trial is illegal

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When B12 levels become problematic: High-dose supplementation (particularly doses exceeding 1,000 micrograms daily) Frequent B12 injections without medical supervision Underlying conditions affecting B12 metabolism Concurrent use of multiple B12-containing supplements The NHS does not set an upper safe limit for vitamin B12 because harmful effects from excessive intake have not been definitively established

Doctors keep an eye out for allergic reactions or heart problems