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One of the most researched of these keystone strains is called Akkermansia muciniphila

Clin Gastroenterol hepatol (2020) 18:196204

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Diagnostic evaluation may include: Detailed neurological examination assessing sensation, reflexes, and motor function Hemoglobin A1c measurement to evaluate recent glycemic control Vitamin B12 levels and methylmalonic acid (if B12 is borderline) Serum protein electrophoresis (SPEP) and immunofixation to screen for paraproteinemia Thyroid function tests, as hypothyroidism can contribute to neuropathic symptoms Comprehensive metabolic panel to assess renal and hepatic function Nerve conduction studies in selected cases with atypical features Management strategies focus on optimizing glycemic control, which remains the most evidence-based intervention for preventing and potentially improving diabetic neuropathy

These differences were recently revealed to have a fundamental impact on the outcome of antagonist engagement of FcRn, as a direct comparison of recombinant versions of efgartigimod (ARGX-113) and two other pipeline antagonistsbatoclimab (HL161BK) and nipocalimab (N027)revealed differential effects on the subcellular trafficking of FcRn [237]

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