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4) Underexplored therapeutic strategies and model limitations: Preclinical studies have relied heavily on lupus-prone mouse models (e.g., MRL/lpr mice), which may not fully recapitulate human LNs complexity (e.g., genetic heterogeneity, variable disease progression, and response to therapy)

It inhibits tyrosinase (the key enzyme that makes dark melanin) and shifts pigment synthesis toward lighter pheomelanin

While regulatory bodies and pharmaceutical companies are discussing potential solutions to the drug shortages, societies such as the American Diabetes Association are providing guidelines to assist with alternative treatment options for patients with type 2 diabetes mellitus as well as guidelines to assist with dosage changes to be made while GLP-1 therapies are low in stock

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Alcohol consumption exacerbates oxidative stress by depleting antioxidant reserves, such as glutathione, and increasing the production of ROS through the metabolism of ethanol

Both companies have massive research pipelines