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Daniela Hurtado Andrade, an endocrinologist at the Mayo Clinic in Jacksonville, Florida, said the lower prices will most likely expand access

Patients with prior gallbladder issues (common in obesity) face compounded risks, as GLP-1s promote rapid weight loss and gallstone formation (2-5% incidence)

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A 2026 review that pooled several controlled trials found that people taking GLP-1 medicines had a clearly higher chance of hair loss than those on placebo, even though the overall chance stayed low

Recent studies further confirmed 5-OH-PA as the most toxic metabolite, causing liver damage and metabolic shifts in rats (Rawat et al., 2018

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