10.1038/s41392-025-02371-z Signal
Upon binding to the erythropoietin receptor (EpoR, located on the surface of erythroid progenitor cells), EPO activates Jak2/STAT5, Ras/Raf/MEK/ERK and PI3K/Akt signaling pathways [41, 42] with consequent downstream recruitment of GATA-1 transcription factor [43], a master regulator of erythropoiesis critically affecting all aspects of cell survival and proliferation
Indeed, short-term glutaminolysis induces mTORC1 lysosomal translocation and activation via the Rag GTPase, then inhibiting autophagy and promoting cell growth [88]
Improved healthspan/lifespan: It maintains metabolic balance and improves physical capacity when given to aged mice [11]
Karppi R, Nyyssnen K, Olsson V, Salonen (2007) Effects of astaxanthin supplementation on lipid peroxidation
Lift heavy twice a week and do brisk walks or cycling on alternate days