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Toxicol Pathol 41: 235-262, 2013

It is classified as a neglected tropical disease

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Compound sources and treatment conditions Palbociclib (PD0332991)-Isethionate (S1579), RSL3 (S8155), ML210 (S0788) and Liproxstatin-1 (S7699) were obtained from Selleckchem

Starting with the lowest effective doses of both compounds and gradually titrating upward allows for better symptom monitoring and safety assessment

Conjugation with glutathione occurs exclusively on the NAPQI and requires an activation of paracetamol by the P450 monooxygenase enzyme complex