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The shots did their job

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Those on the highest dose (12 mg weekly, administered via subcutaneous injection) achieved an average body weight reduction of 24.2% at 48 weeks

doi: 10.1016/j.brainres.2015.12.052 164 QiLKeLLiuXLiaoLKeSLiuXet al

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This guide provides complete nasal spray preparation from reconstituted PT-141 , proper nasal administration technique step-by-step, dosing adjustments for nasal vs injectable routes , timing optimization for maximum effects, managing nasal-specific side effects, comparing nasal spray efficacy to subcutaneous injection , and determining when nasal spray makes sense versus accepting injection requirements