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If blood glucose control improves significantly, doses of insulin or sulfonylureas (if used) may need adjustment under medical supervision to reduce the risk of hypoglycaemia

Xie Z, Enkhjargal B, Wu L, Zhou K, Sun C, Hu X, et al

Change them more often if they become wet with drainage

Low-dead-volume syringes exist and reduce this loss by 50 to 80%, which may be worth the investment for expensive peptides

Specialist referral to tier 3 weight management services or bariatric surgery assessment may be appropriate for individuals with BMI 40 kg/m or 35 kg/m with significant comorbidities who have not achieved adequate weight loss with conventional measures

The right choice depends on your health, goals, and supervised medical guidance