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Paradoxically, the restoration of blood flow during reperfusion exacerbates the injury through mechanisms involving oxidative stress, inflammation, and endothelial dysfunction [3]

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Epigenetic PTEN silencing in malignant melanomas without PTEN mutation

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Luo et al found that TMAO may inhibit the expression of nuclear factor E2-related factor 2 (Nrf2), HO-1, and glutathione peroxidase 4 (GPX4), resulting in the overproduction of ROS and the reduction of SOD activity, thus promoting oxidative stress

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Reduced Nm23/Awd protein in tumour metastasis and aberrant Drosophila development

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Patients were randomized to several groups, including topical melatonin only, topical melatonin plus screen, and a combination of topical and oral melatonin and hydroquinone 4% for 90 days

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