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The majority of these follow-on patents were filed between 2021 and 2022, coinciding with the launches of Mounjaro and Zepbound (Figure 10)

Compared with full basal-bolus insulin regimens, the combination of GLP-1 agonist plus insulin resulted in a marginal 0.1% reduction in HbA1c, a 33% lower risk of hypoglycaemia and a mean 5.66-kg reduction in weight

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A 2025 review summarizing the sperm data noted that a randomized trial reported a modest improvement in sperm shape after 24 weeks of semaglutide, though other measures did not clearly change [1]

This interaction between ghrelin and leptin in control of food intake is called "argentinian ghrelin-leptin tango" ( Fig