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DSIP does not belong clearly to a recognised family of endogenous neuropeptide hormones

Mechanistic gaps in pathway crosstalk and causality: Current studies have primarily focused on individual pathways (e.g., Nrf2-mediated antioxidant defense and TGF-/SmadHDAC3-driven fibrosis) but lack insights into the core molecular hubs integrating these networks

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10.1007/s11255-018-1911-0 Int Urol Nephrol

the full protein and the synthetic fragment have distinct research applications

This coordination stabilizes copper in a biologically available form, allowing it to interact with cellular targets without generating oxidative stress. The copper ion also acts as a catalytic cofactor in enzymes involved in collagen cross-linking, antioxidant defense, and wound remodeling