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New dual agonists (GIP/GLP-1) are showing profound impact not only on weight loss and glycemic control but also on cardiovascular outcomes

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The same applies to Phentermine

Excessive ROS generation and oxidative stress exacerbate pancreatic cell injury, promote inflammatory responses, and ultimately lead to extensive pancreatic tissue damage and functional failure (117)

However, timing varies based on the peptide and the individuals health

The results of this study showed that metformin and acarbose mainly exerted different interactive effects with dietary energy, carbohydrate, and protein intakes on GLP-1 secretion, insulin release, and SBP