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If you notice a significant increase in anxiety after starting Mounjaro, speak to your prescriber

Take home message At standard doses, Mounjaro produces greater average weight loss than Wegovy (20.2% vs 13.7% in clinical trials)

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Symptoms Most Likely To Improve (Fullness, Gas, Post-Meal Heaviness) Based on physiology and real-world reports, digestive enzymes are most plausible for: Post-meal heaviness or a "brick in your stomach" feeling after certain meals Gas and bloating that seems meal-triggered (especially after fatty foods, dairy, or higher-FODMAP carbohydrate loads) A sense of prolonged fullness that feels more like slow breakdown than medication-induced nausea If your bloating is primarily from fermentation (for example, certain fibers and carbohydrates that feed gas-producing bacteria), enzymes like alpha-galactosidase can be helpful because they break down specific fermentable carbs before your gut bacteria get to them

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Riboflavin (vitamin B2) supports breakdown of n-methyl histamine