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In an experimental model of abdominal aortic aneurysm, topiramate markedly downregulated pro-inflammatory M1 macrophage activity, reduced the expression of TNF-, IL-1, and matrix metalloproteinase-9, and promoted a phenotypic shift of macrophages from M1 to M2, thereby mitigating pro-inflammatory activity and enhancing tissue repair processes ( These studies collectively suggest that topiramate exerts significant neuroprotective effects across various pathological models through its potent anti-inflammatory properties

Design and optimization of crocetin-loaded PLGA nanoparticles against diabetic nephropathy via suppression of inflammatory biomarkers: a formulation approach to preclinical study

The quinine hemisulfate solution with a known \(\phi\) value of 54% was prepared in 0.5 M sulfuric acid.The excitation wavelength utilized for this measurement was set at 340 nm