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Simultaneous determination of superoxide dismutase and catalase in biological materials by polarography

Pharmacological targeting of CHAC1-mediated processes therefore represents a rational therapeutic strategy, potentially disrupting the cycle of GSH depletion, ER stress amplification and iron-dependent peroxidation that drives neuronal loss

doi: 10.1038/s41584-025-01223-y 2 GBD 2021 Osteoarthritis Collaborators

doi: 10.1080/21623945.2021.1965314 153 FeuererMHerreroLCipollettaDNaazAWongJNayerAet al

Nuzzo D, Picone P

Generation of CRISPR KO strains To generate a knockout of glutathione reductase (GSR) in HEK293 cells, a guide RNA sequence targeting exon 1 was cloned into the pSpCas9(BB)-2A-GFP (PX458) vector, gifted from Feng Zhang (Addgene plasmid #48138, Watertown, MA, United States) 84