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These medications act on brain pathways involved in reward and motivation

Supporting evidence for the prefrontal hypodopaminergia came from PET (positron emission tomography) studies showing reduced cerebral blood flow in frontal cortex, which was directly correlated with low cerebrospinal fluid (CSF) DA metabolite levels in schizophrenia patients

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In addition to renal activation, peripheral tissues such as immune cells also express CYP27B1, indicating that vitamin D can be locally activated to exert paracrine effects (7)

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The body did it