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Using chemogenetic, optogenetic, and viral tracing strategies to study how GLP-1 signals in the brain impact liver fibrosis and inflammation is an area of intense basic investigation

The mechanism involves direct action on GLP-1 receptors in the liver

There are also some relevant studies investigating the effects of semaglutide in animal models

People with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2 should not use GLP-1 medications