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Patients with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2 (MEN 2) should not take GLP-1 medications with the thyroid C-cell tumor boxed warning

We performed a meta-analysis that included all 8 CVOTs using the Cochrane Collaborations Review Manager Software Package (RevMan 5.3) and found significant decreases versus placebo in fatal/nonfatal stroke (HR, 0.83 [95% CI, 0.760.92]), nonfatal stroke (HR, 0.84 [95% CI, 0.760.93]), but no reduction in fatal stroke (HR, 0.80 [95% CI, 0.631.03]

Food Preservation 5.4.3.3.10

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These effects are often transient and may diminish with continued exposure