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[DOI] [PMC free article] [PubMed] [Google Scholar] 212.Hajihashemi P., Askari G., Khorvash F., Reza Maracy M., Nourian M

Science-Backed GLP-1 medications, like Zepbound are FDA-approved for type 2 diabetes and have proven effective for weight loss

[DOI] [PubMed] [Google Scholar] 105.Gamulin O., Oroz K., Coric L., Krajacic M., Skrabic M., Dretar V., Strbe S., Talapko J., Juzbasic M., Krezic I., et al

250 A multicenter, randomized, double-blind, placebo-controlled phase II study validated that RT100, an AdV5-encoded AC6 gene therapy, safely increased left ventricular function beyond standard HF treatments

A more detailed discussion of safety and tolerability are provided later

The short duration of action needed to be addressed to exploit the promising effects of GLP- 1 for the development of a clinically beneficial drug