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Complementarity with Cell Therapy Cell therapy remains a comprehensive and powerful approach, as living cells can adapt to the microenvironment, secrete dozens of factors simultaneously, and interact dynamically with damaged tissues

While its clinical performance suggests that dual incretin agonism may redefine treatment expectations, careful integration into clinical practice will require continued evaluation of long term outcomes, comparative effectiveness, and health system implications

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Incretin receptor activation can also ameliorate insulin signaling by reducing aberrant IRS-1 phosphorylation and Akt activation in multiple PD experimental systems (Long-Smith et al., 2013)