Unsaturated VPA metabolites (4-en-VPA and 2, 4-dien-VPA) are potent inducers of microvesicular steatosis in rats, whereas VPA itself failed to induce discernible liver lesions at near lethal doses [60]
The completion of the trial allows Lilly to seek regulatory approval and potentially launch the next-generation drug in 2027 as it competes with Novo Nordisk in the obesity treatment market
Liting Jiang, [email protected] These authors have contributed equally to this work and share the first authorship Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers
A lower GSH/GSSG ratio generally indicates a more oxidized glutathione pool, but it does not identify the cause
Ann N Y Acad Sci 1033:3041 Reuter SE, Evans AM (2012) Carnitine and acylcarnitines: pharmacokinetic, pharmacological and clinical aspects
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