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GPCR Biased Signaling Evaluation of Dual and Triple-receptor Agonist Against GLP-1, GIP, and Glucagon Receptors

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The receptors were observed to be located within structures influencing feeding behavior, like the hypothalamus, brainstem, and circumventricular organs like the median eminence and area postrema [45]

Chronic stress elevates cortisol, which can increase appetite and promote cravings for high-calorie foods