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This additional indication was based on results from a multinational clinical trial showing that Wegovy reduced the risk of major adverse cardiovascular events (MACE) by 20%
It supports tendon-to-bone attachment in models
The apo-peptide GHK (without copper) has reduced or absent activity in many of the contexts where the copper-bound form has been characterized, reflecting the copper-dependent nature of much of the biology
Therefore, if retatrutide receives approval as a weight loss medication, it could potentially facilitate additional reductions in fat mass for patients who have previously been treated with semaglutide
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Eur J Endocrinol (2015) 173:65564
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