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Not that its wrong to do simulations, perhaps wrong to promote them like salesmen not researchers, as the final answer

2 More severe obesity, defined as a BMI above 40, can cut eight to ten years from expected lifespan

20 Participants were randomized to saxagliptin groups at 2.5 mg, 5 mg, and 10 mg in combination with metformin doses ranging from 500 to 2,550 mg/day at study entry

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