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Tirzepatide will not only be widely used (currently, the production lags substantially behind the number of prescriptions), but it will make possible studies identifying the optimum glycaemic targets (even into the normal range)

I personally go for the 500mg dose because that is what I usually use and the difference between the two is 20p or 24p per serving so you get double dose for only 4p more per serving so makes economic sense too

The Science of the Steady State To understand why timing is flexible, it helps to understand how tirzepatide works in the body

Blood tests may be needed to determine deficiencies and proper dosing

Real-world data link skipped titration to higher discontinuation rates, which is why the step-up approach is standard

However, frail elderly patients and those over 80 years are often underrepresented in clinical trials, meaning real-world clinical judgement is paramount