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Key to immune system function are two phenotypic types of macrophages, M1 and M2 (8, 163, 164)

However, in 2022, a PD clinical trial with the iron chelator deferiprone showed that, despite effectively reducing brain iron levels, deferiprone was associated with worsening motor and nonmotor symptoms 209

In addition, NAFLD was associated with a significantly increased risk of hyperhomocysteinemia (Odds ratio = 5.01, CI 1.69, 15.32) 24

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In the modified intent-to-treat population (n = 145), the mean ln ratio in PWT was 0.241 for the cilostazol + L-carnitine treatment group versus 0.134 for the cilostazol + placebo treatment group (p = 0.076)