5-Amino-1MQ vs AOD-9604: Key Takeaways 5-Amino-1MQ and AOD-9604 are both powerful fat-loss agents but their strengths come from entirely different mechanisms: 5-Amino-1MQ Inhibits NNMT to preserve NAD, activate SIRT1, elevate basal metabolic rate, and improve metabolic flexibility (Kraus et al., Nature Medicine )
Great for dark spots, and works amazingly in conjunction with retinol, but needs to be introduced slowly. It also has antibacterial and anti-inflammatory properties, making it ideal for acne-prone or rosacea-prone skin types
Gabrielle Lyon on the cover, available in stores and online on January 20, 2026
A 2021 peer-reviewed review of NNMT in obesity and type 2 diabetes states explicitly that 'clinical trials targeting NNMT have not been reported' meaning every quantitative efficacy figure available for this compound comes from mice, and there is currently zero published human efficacy data
Ablation of p75NTR signaling strengthens gammatheta rhythm interaction and counteracts A-induced degradation of neuronal dynamics in mouse hippocampus in vitro
The lack of a single target has made DSIP harder to develop as a pharmaceutical, but the same versatility is partly why it has attracted research interest across different therapeutic areas
