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Hydrolysis: Cleavage of the peptide bonds under stressed conditions (heat, pH shifts)

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In 1 small study, women with poorer mean preconception creatinine clearance (CrCl) of 61 mL/min/1.73 m During pregnancy, serum creatinine (not eGFR) should be used, as eGFR will underestimate GFR in pregnancy (57,58)