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The authors reported that AOD-9604 stimulated lipolysis in isolated adipocytes and that chronic daily treatment in obese Zucker rats produced reductions in body weight gain of more than 50% relative to untreated controls over the treatment period, without effects on insulin sensitivity or IGF-1 levels [3]

This effort led to the development of Dihexa (N-hexanoic-Tyr-Ile-(6)-aminohexanoic amide), a key focus of this study [2]

Tyrosinase activity can also increase the risk of developing hyperpigmentation of the cheeks, forehead, and upper lip, a condition known as melasma, which may remain after pregnancy

Decreased interstitial SA--gal activity and lowered levels of senescence-associated proteins p53, p21, and p16

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The peptide itself is essentially a copper-delivery vehicle, without intact Cu coordination (color check: deep blue), the molecule loses most of its biological activity